Historical Background
The ability of cells to sense, respond, and adapt to their environment is essential for multicellular life. SLC3A2 protein provides cells with the capacity of adjusting to their surroundings by mediating two fundamental molecular functions: amino acid transport and integrin signaling.
SLC3A2 is involved in many cellular processes, such as early activation of T and B cells (Cantor et al. 2009, 2012), cell fusion (Deves et al. 2000; Takesono et al. 2012), cell survival and migration (Feral et al. 2005), cell proliferation (Cantor et al. 2009; Boulter et al. 2013; de la Ballina et al. 2016), mechanotransduction (Estrach et al. 2014), and angiogenesis ( Liao et al. 2016). Thus, SLC3A2 is crucial for responding to different cellular stresses (i.e., oxidative or nutritional stress (de la Ballina et al. 2016), lack...
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de La Ballina, L.R., de Garay, T., Féral, C.C., Palacín, M. (2018). SLC3A2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101895
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101895
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