Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

TRAP1

  • Danilo Swann Matassa
  • Ilenia Agliarulo
  • Maria Rosaria Amoroso
  • Rosario Avolio
  • Matteo Landriscina
  • Franca Esposito
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101888

Synonyms

Historical Background

TNF receptor-associated protein 1 (TRAP1) was firstly identified by a yeast-based two-hybrid system as a novel protein binding the intracellular domain of the type 1 receptor for tumor necrosis factor (TNFR-1IC), hence its name. The protein immediately showed strong sequence homology with members of the heat shock proteins 90-kDa (HSP90) family and variable expression levels in human skeletal muscle, liver, heart, brain, kidney, pancreas, lung, and placenta and in eight different transformed cell lines (Song et al. 1995). A second, independent yeast two-hybrid screening led to the identification of a new heat shock protein functioning as a molecular chaperone for the retinoblastoma protein (Rb). Antibodies prepared against fusion protein between glutathione S-transferase and domains of this new heat shock protein...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Dipartimento di Medicina Molecolare e Biotecnologie MedicheUniversità di Napoli “Federico II”NaplesItaly
  2. 2.Dipartimento di Scienze Mediche e ChirurgicheUniversità di Foggia/Laboratori di Ricerca Preclinica e Traslazionale, IRCCS, Centro di Riferimento Oncologico della BasilicataFoggiaItaly