Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Transient Receptor Potential Cation Channel Subfamily M Member 2

  • Lin-Hua JiangEmail author
  • Sharifah Alawieyah Syed Mortadza
Reference work entry
First Online:
DOI: https://doi.org/10.1007/978-3-319-67199-4_101875
How to cite

Synonyms

 Classical transient receptor potential 7;  Long transient receptor potential channel 2;  LTRPC2;  Melastatin-related transient receptor potential 2;  Transient receptor potential melastatin-related 2;  TRPC7;  TRPM2

Historical Background

Transient receptor potential (TRP) cation channel subfamily M member 2 (TRPM2) was identified in the search for mammalian genes encoding homologues of the transient receptor potential (Trp) proteins that forms Ca2+-permeable cationic channels required for photo-transduction in Drosophila melanogaster fruit fly (Hardie and Minke 1992). It was firstly named the seventh classical TRP protein (TRPC7) that exhibits sequence relatedness with Drosophila Trp proteins (Nagamine et al. 1998) and subsequently renamed LTRPC2, the second member of the long TRP channel protein family characterized with exceptionally long N- and C-termini (Harteneck et al. 2000). In the efforts devoted to unifying the terminology, the mammalian TRP proteins, 28 in total,...

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Notes

Acknowledgments

SSM is a recipient of Malaysian governmental scholarship. The researches in LHJ's lab described here have been supported by Wellcome Trust, Alzheimer’s Research Trust, Nature Science Foundation of China, Department of Education Henan Province, and Xinxiang Medical University. We apologize that we have not cited the literature in full due to space limitation.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Lin-Hua Jiang
    • 1
    • 2
    Email author
  • Sharifah Alawieyah Syed Mortadza
    • 1
  1. 1.School of Biomedical SciencesUniversity of LeedsLeedsUK
  2. 2.Department of Physiology and Neurobiology, and Sino-UK Joint Laboratory of Brain Function and InjuryXinxiang Medical UniversityXinxiangChina