Steroidogenic factor 1 (SF-1), also called Adrenal 4 binding protein (Ad4BP), was originally discovered in the early 1990s by Drs. Parker and Morohashi as a regulator of steroid hydroxylases in adrenal glands (Lala et al. 1992; Morohashi et al. 1992). It is a transcription factor, member of the nuclear receptors superfamily. Official designation of the gene encoding for SF-1 is NR5a1, although in the literature the name SF-1 is still predominantly used, and therefore, we will use this designation throughout this chapter.
Numerous studies have shown wide role of SF-1 in the endocrine development and function beyond regulation of steroid hydroxylases. In particularly, studies with SF-1 knockout (SF-1 KO) mice have shown the importance of SF-1 for adrenal and gonadal development, development of the ventromedial nucleus of the hypothalamus (VMH), and spleen and pituitary gonadotropin-producing...
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