Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

SYK

  • Robert L. Geahlen
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101869

Synonyms

Historical Background

Catalytic activity corresponding to the SYK kinase was first detected in extracts from bovine thymus based on the phosphorylation on tyrosine of a synthetic peptide substrate. Purification of this activity by conventional column chromatographic approaches led to the isolation of an enzyme with a molecular mass of 40 kDa that was originally referred to as p40 (Zioncheck et al. 1986). Shortly thereafter, the same catalytic fragment was identified and purified from porcine spleen and given the name CPTK40 (Kobayashi et al. 1990). The fact that these two kinases were actually catalytic fragments was recognized when antibodies generated against p40 revealed a larger precursor of 72 kDa, the proteolytic cleavage of which yielded the activated 40 kDa fragment (Zioncheck et al. 1988). The full-length protein was originally referred to as PTK72. Similarly, the screening of a porcine cDNA...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Medicinal Chemistry and Molecular PharmacologyPurdue UniversityWest LafayetteUSA