Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Valérie DrouetEmail author
  • Suzanne Lesage
  • Alexis Brice
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101866


Historical Background

Synaptojanin 1 (SYNJ1) was discovered in 1994 as a brain-specific 145 kDa protein interacting with growth factor receptor-bound protein 2 (Grb2) and the phosphoprotein dynamin, involved in synaptic vesicle endocytosis and recycling (McPherson et al. 1994). SYNJ1 is a multidomain protein with a dual phosphoinositide phosphatase activity and is required for proper synaptic activity. Due to its high concentration in nerve terminals, its role in endocytosis has been widely studied and will be developed further in this article, but other unexpected roles are now emerging in different cell types and model organisms. In addition to its presynaptic functions, SYNJ1 is involved in internalization of AMPA...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Valérie Drouet
    • 1
    • 2
    • 3
    • 4
    Email author
  • Suzanne Lesage
    • 1
    • 2
    • 3
    • 4
  • Alexis Brice
    • 1
    • 2
    • 3
    • 4
    • 5
  1. 1.UPMC Université Paris 6 UMR S 1127Sorbonne UniversitésParisFrance
  2. 2.Inserm U 1127, 75013ParisFrance
  3. 3.CNRS UMR 7225ParisFrance
  4. 4.Institut du Cerveau et de la Moelle épinière, ICMParisFrance
  5. 5.Department of Genetics and CytogeneticsAP-HP, Hôpital de la SalpêtrièreParisFrance