Tcf1 transcription factor is a member of the Tcf/Lef family which consists of four members in vertebrates. Its orthologs in invertebrates include dTCF/pangolin in Drosophila and POP-1 in C. elegans (Arce et al. 2006; Cadigan 2012). Tcf1 was molecularly cloned in 1991 and found to be most abundantly expressed in T lymphocytes. In 1996, Lef1, a close homologue of Tcf1, was found to interact with β-catenin which is posttranslationally regulated by the Wnt signaling pathway. Since then, Tcf1, together with other members of Tcf/Lef family, is considered a Wnt effector transcription factor (Klaus and Birchmeier 2008). However, research efforts over the past two-and-half decades have revealed that Tcf1 interacts with several other transcription factors and cofactors, in addition to β-catenin, to cooperatively regulate gene transcription (Steinke and Xue 2014).
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