Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Tcf1

  • Dong-Mei Zhao
  • Hai-Hui Xue
Reference work entry
First Online:
DOI: https://doi.org/10.1007/978-3-319-67199-4_101862
How to cite

Synonyms

 T cell factor 1;  TCF-1;  Tcf7;  Transcription factor 7, T cell specific transcription factor 1

Historical Background

Tcf1 transcription factor is a member of the Tcf/Lef family which consists of four members in vertebrates. Its orthologs in invertebrates include dTCF/pangolin in Drosophila and POP-1 in C. elegans (Arce et al. 2006; Cadigan 2012). Tcf1 was molecularly cloned in 1991 and found to be most abundantly expressed in T lymphocytes. In 1996, Lef1, a close homologue of Tcf1, was found to interact with β-catenin which is posttranslationally regulated by the Wnt signaling pathway. Since then, Tcf1, together with other members of Tcf/Lef family, is considered a Wnt effector transcription factor (Klaus and Birchmeier 2008). However, research efforts over the past two-and-half decades have revealed that Tcf1 interacts with several other transcription factors and cofactors, in addition to β-catenin, to cooperatively regulate gene transcription (Steinke and Xue 2014).

Tcf1...

This is a preview of subscription content, log in to check access.

References

  1. Arce L, Yokoyama NN, Waterman ML. Diversity of LEF/TCF action in development and disease. Oncogene. 2006;25:7492–504.  https://doi.org/10.1038/sj.onc.1210056.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Cadigan KM. TCFs and Wnt/beta-catenin signaling: more than one way to throw the switch. Curr Top Dev Biol. 2012;98:1–34.  https://doi.org/10.1016/B978-0-12-386499-4.00001-X.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X, et al. TCF1 links GIPR signaling to the control of beta cell function and survival. Nat Med. 2016;22:84–90.  https://doi.org/10.1038/nm.3997.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Choi YS, Gullicksrud JA, Xing S, Zeng Z, Shan Q, Li F, et al. LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6. Nat Immunol. 2015;16:980–90.  https://doi.org/10.1038/ni.3226.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Collins A, Littman DR, Taniuchi I. RUNX proteins in transcription factor networks that regulate T-cell lineage choice. Nat Rev Immunol. 2009;9:106–15.  https://doi.org/10.1038/nri2489.CrossRefPubMedPubMedCentralGoogle Scholar
  6. De Obaldia ME, Bhandoola A. Transcriptional regulation of innate and adaptive lymphocyte lineages. Annu Rev Immunol. 2015;33:607–42.  https://doi.org/10.1146/annurev-immunol-032414-112032.CrossRefPubMedPubMedCentralGoogle Scholar
  7. He R, Hou S, Liu C, Zhang A, Bai Q, Han M, et al. Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection. Nature. 2016a;537:412–28.  https://doi.org/10.1038/nature19317.CrossRefPubMedPubMedCentralGoogle Scholar
  8. He B, Xing S, Chen C, Gao P, Teng L, Shan Q, et al. CD8+ T cells utilize highly dynamic enhancer repertoires and regulatory circuitry in response to infections. Immunity. 2016b;45:1341–54.  https://doi.org/10.1016/j.immuni.2016.11.009PubMedPubMedCentralCrossRefGoogle Scholar
  9. Im SJ, Hashimoto M, Gerner MY, Lee J, Kissick HT, Burger MC, et al. Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. Nature. 2016;537:417–21.  https://doi.org/10.1038/nature19330.CrossRefPubMedPubMedCentralGoogle Scholar
  10. Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer. 2008;8:387–98.  https://doi.org/10.1038/nrc2389.CrossRefPubMedPubMedCentralGoogle Scholar
  11. Leong YA, Chen Y, Ong HS, Wu D, Man K, Deleage C, et al. CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles. Nat Immunol. 2016;17:1187–96.  https://doi.org/10.1038/ni.3543.CrossRefPubMedPubMedCentralGoogle Scholar
  12. Roose J, Huls G, van Beest M, Moerer P, van der Horn K, Goldschmeding R, et al. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science. 1999;285:1923–6.PubMedPubMedCentralCrossRefGoogle Scholar
  13. Steinke FC, Xue HH. From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells. Immunol Res. 2014;59:45–55.  https://doi.org/10.1007/s12026-014-8545-9.CrossRefPubMedPubMedCentralGoogle Scholar
  14. Steinke FC, Yu S, Zhou X, He B, Yang W, Zhou B, et al. TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells. Nat Immunol. 2014;15:646–56.  https://doi.org/10.1038/ni.2897.CrossRefPubMedPubMedCentralGoogle Scholar
  15. Wu T, Shin HM, Moseman EA, Ji Y, Huang B, Harly C, et al. TCF1 is required for the T follicular helper cell response to viral infection. Cell Rep. 2015.  https://doi.org/10.1016/j.celrep.2015.08.049.CrossRefPubMedPubMedCentralGoogle Scholar
  16. Xing S, Li F, Zeng Z, Zhao Y, Yu S, Shan Q, et al. Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity. Nat Immunol. 2016;17:695–703.  https://doi.org/10.1038/ni.3456.CrossRefPubMedPubMedCentralGoogle Scholar
  17. Xu L, Cao Y, Xie Z, Huang Q, Bai Q, Yang X, et al. The transcription factor TCF-1 initiates the differentiation of TFH cells during acute viral infection. Nat Immunol. 2015;16:991–9.  https://doi.org/10.1038/ni.3229.CrossRefPubMedPubMedCentralGoogle Scholar
  18. Xue HH, Zhao DM. Regulation of mature T cell responses by the Wnt signaling pathway. Ann NY Acad Sci. 2012;1247:16–33.  https://doi.org/10.1111/j.1749-6632.2011.06302.x.CrossRefPubMedPubMedCentralGoogle Scholar
  19. Yang Q, Li F, Harly C, Xing S, Ye L, Xia X, et al. TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nat Immunol. 2015;16:1044–50.  https://doi.org/10.1038/ni.3248.CrossRefPubMedPubMedCentralGoogle Scholar
  20. Yu S, Li F, Xing S, Zhao T, Peng W, Xue HH. Hematopoietic and leukemic stem cells have distinct dependence on Tcf1 and Lef1 transcription factors. J Biol Chem. 2016;291:11148–60.  https://doi.org/10.1074/jbc.M116.717801.CrossRefPubMedPubMedCentralGoogle Scholar
  21. Yu S, Zhou X, Steinke FC, Liu C, Chen SC, Zagorodna O, et al. The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity. 2012;37:813–26.  https://doi.org/10.1016/j.immuni.2012.08.009.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Internal MedicineIowa City Veteran Affairs Health Care SystemsIowa CityUSA
  2. 2.Department of Microbiology, Carver College of MedicineUniversity of IowaIowa CityUSA