SLC24A Family (K+-Dependent Na+-Ca2+ Exchanger, NCKX)
Tightly controlled changes in cytosolic free Ca2+ concentration are widely involved in cell signaling in most tissues of our body. Free Ca2+ concentration is increased through the activation of a wide range of surface or intracellular Ca2+ channels and is returned to resting values through the action of ATP-driven Ca2+ pumps located in the plasma membrane and endoplasmic reticulum as well as Na+/Ca2+ exchangers located on the plasma membrane. By the mid 1980s, it had been established that the surface membrane of the outer segments of retinal rod photoreceptors (ROS) contained a potent Na+-Ca2+ exchange mechanism (Schnetkamp 1980; Yau and Nakatani 1984), and, in 1988, the Na+-Ca2+ exchanger protein was purified from bovine ROS as a 220 kDa glycoprotein (Cook and Kaupp 1988). In...
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