Na+/HCO3− Cotransporter NBCn1
NBCn1 is an electroneutral Na+/HCO3− cotransporter encoded by SLC4A7 gene, a member of the bicarbonate transporter family of solute carrier 4 (SLC4). In total, this family contains ten members: (1) three electroneutral anion exchangers AE1 (SLC4A1), AE2 (SLC4A2), and AE3 (SLC4A3); (2) five Na+-coupled HCO3− transporters (NCBTs), including two electrogenic Na+/HCO3− cotransporters NBCe1 (SLC4A4), NBCe2 (SLC4A5), two electroneutral Na+/HCO3− cotransporters NBCn1 and NBCn2 (SLC4A10), and an electroneutral Na+-driven Cl−/HCO3− exchanger NDCBE (SLC4A8); (3) two less well-characterized members SLC4A9 and SLC4A11.
The association between the transport of Na+ and HCO3− was reported in 1970s in epithelial cells from different systems, such as proximal tubules (Burg and Green 1977) and jejunum (Turnberg et al. 1970; Podesta and Mettrick 1977). In 1983, Boron and Boulpaep clearly conceptualized for the first time Na+/HCO3−...
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