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Encyclopedia of Signaling Molecules pp 4652–4657Cite as

Retinol-Binding Protein 4 (RBP4)

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Synonyms

Plasma retinol-binding protein; PRBP; RBP; RBP retinol-binding protein; RBP4

Historical Background

Retinol-binding protein 4 (RBP4), previously known as RBP, is a career of retinol in plasma that transport retinol from liver to peripheries. This protein mainly produced by liver and partly from adipose tissue RBP4 is encoded by the Rbp4 gene, localized in the chromosome 10q23-q24 including 8 exons. The lack of RBP4 leads to vitamin A deficiency in Rbp4 knockout mice. RBP4 that is not bound to retinol is called as Apo-RBP4, whereas retinol-bound RBP4 (holo- RBP4) associates with transthyretin (TTR) in plasma in order to stop RBP to be lost during kidney filtration. Stimulated by retinoic acid 6 (STRA6) is the cell surface receptor for RBP4. For years RBP4 was known just as a vitamin A career and a negative phase marker of acute inflammation; however, recent studies provided a novel insight to RBP4 and its role in inflammation and obesity-related complications including insulin...

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Author information

Authors and Affiliations

  1. Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia

    Fateme Zabetian-Targhi

  2. Department of Cellular Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

    Maryame Mahmoudi

  3. Pediatric Gastroenterology and Hepatology Research Center, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Maryame Mahmoudi

  4. Dietetics and Nutrition Experts Team (DiNET), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Maryame Mahmoudi

Authors
  1. Fateme Zabetian-Targhi
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  2. Maryame Mahmoudi
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Corresponding author

Correspondence to Maryame Mahmoudi .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Zabetian-Targhi, F., Mahmoudi, M. (2018). Retinol-Binding Protein 4 (RBP4). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101853

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