Historical Background
CD28 was identified in early 1980s by Martin and colleagues by monoclonal antibodies recognizing a 44 kDa protein on the surface of human T lymphocytes (Martin et al. 1980). Further experiments from Gmunder and Lessener evidenced the crucial role of this molecule in costimulating T cell responses by synergizing with PHA in inducing T cell proliferation (Gmunder and Lesslauer 1984). Later in 1987, Aruffo and Seed cloned the cDNA of human CD28 and showed that it encodes for a 23 kDa glycosylated type I transmembrane protein expressed as disulfide-linked homodimer on the surface of 80% of human CD4+ T cells and 50% of human CD8+ T cells (Aruffo and Seed 1987). In mouse, CD28 was cloned in 1990 by Gross and colleagues and found to be expressed 100% on both CD4+ and CD8+ T cells (Gross et al. 1990). In the same year, the natural ligands of CD28 were also identified. In 1989,...
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References
Acuto O, Cantrell D. T cell activation and the cytoskeleton. Annu Rev Immunol. 2000;18:165–84. https://doi.org/10.1146/annurev.immunol.18.1.165.
Acuto O, Michel F. CD28-mediated co-stimulation: a quantitative support for TCR signalling. Nat Rev Immunol. 2003;3:939–51. https://doi.org/10.1038/nri1248.
Aruffo A, Seed B. Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. Proc Natl Acad Sci USA. 1987;84:8573–7.
Azuma M, Ito D, Yagita H, Okumura K, Phillips JH, Lanier LL, et al. B70 antigen is a second ligand for CTLA-4 and CD28. Nature. 1993;366:76–9. https://doi.org/10.1038/366076a0.
Boomer JS, Green JM. An enigmatic tail of CD28 signaling. Cold Spring Harb Perspect Biol. 2010;2:a002436. https://doi.org/10.1101/cshperspect.a002436.
Freeman GJ, Freedman AS, Segil JM, Lee G, Whitman JF, Nadler LM. B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol. 1989;143:2714–22.
Freeman GJ, Gribben JG, Boussiotis VA, Ng JW, Restivo Jr VA, Lombard LA, et al. Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science. 1993;262:909–11. https://doi.org/10.1126/science.7694363.
Gmunder H, Lesslauer W. A 45-kDa human T-cell membrane glycoprotein functions in the regulation of cell proliferative responses. Eur J Biochem. 1984;142:153–60. https://doi.org/10.1111/j.1432-1033.1984.tb08263.x.
Gross JA, St John T, Allison JP. The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression. J Immunol. 1990;144:3201–10.
Lin CH, Hunig T. Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist. Eur J Immunol. 2003;33:626–38. https://doi.org/10.1002/eji.200323570.
Martin PJ, Hansen JA, Nowinski RC, Brown MA. A new human T-cell differentiation antigen: unexpected expression on chronic lymphocytic leukemia cells. Immunogenetics. 1980;11:429–39.
Muscolini M, Camperio C, Porciello N, Caristi S, Capuano C, Viola A, et al. Phosphatidylinositol 4-phosphate 5-kinase alpha and Vav1 mutual cooperation in CD28-mediated actin remodeling and signaling functions. J Immunol. 2015;194:1323–33. https://doi.org/10.4049/jimmunol.1401643.
Porciello N, Tuosto L. CD28 costimulatory signals in T lymphocyte activation: emerging functions beyond a qualitative and quantitative support to TCR signalling. Cytokine Growth Factor Rev. 2016;28:11–9. https://doi.org/10.1016/j.cytogfr.2016.02.004.
Rudd CE, Schneider H. Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nat Rev Immunol. 2003;3:544–56. https://doi.org/10.1038/nri1131.
Shapiro VS, Truitt KE, Imboden JB, Weiss A. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Mol Cell Biol. 1997;17:4051–8.
Suntharalingam G, Perry MR, Ward S, Brett SJ, Castello-Cortes A, Brunner MD, et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med. 2006;355:1018–28. https://doi.org/10.1056/NEJMoa063842.
Tavano R, Contento RL, Baranda SJ, Soligo M, Tuosto L, Manes S, et al. CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse. Nat Cell Biol. 2006;8:1270–6. https://doi.org/10.1038/ncb1492.
Tuosto L. NF-kappaB family of transcription factors: biochemical players of CD28 co-stimulation. Immunol Lett. 2011;135:1–9. https://doi.org/10.1016/j.imlet.2010.09.005.
Verweij CL, Geerts M, Aarden LA. Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element. J Biol Chem. 1991;266:14179–82.
Viola A, Contento RL, Molon B. Signaling amplification at the immunological synapse. Curr Top Microbiol Immunol. 2010;340:109–22. https://doi.org/10.1007/978-3-642-03858-7_6.
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Tuosto, L. (2018). CD28. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101843
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