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SLC28 and SLC29

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Encyclopedia of Signaling Molecules

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References

  • Baldwin SA, Yao SY, Hyde RJ, Ng AM, Foppolo S, Barnes K, Ritzel MW, Cass CE, Young JD. Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J Biol Chem. 2005;280:15880–7.

    Article  PubMed  CAS  Google Scholar 

  • Barnes K, Dobrzynski H, Foppolo S, Beal PR, Ismat F, Scullion ER, Sun L, Tellez J, Ritzel MW, Claycomb WC, Cass CE, Young JD, Billeter-Clark R, Boyett MR, Baldwin SA. Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH. Circ Res. 2006;99:510–9.

    Article  PubMed  CAS  Google Scholar 

  • Chen J, Rinaldo L, Lim SJ, Young H, Messing RO, Choi DS. The type 1 equilibrative nucleoside transporter regulates anxiety-like behavior in mice. Genes Brain Behav. 2007;6:776–83.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Errasti-Murugarren E, Molina-Arcas M, Casado FJ, Pastor-Anglada M. A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 (hCNT3) protein localized in the endoplasmic reticulum. FASEB J. 2009;23:172–82.

    Article  PubMed  CAS  Google Scholar 

  • Govindarajan R, Leung GPH, Zhou MY, Tse CM, Wang J, Unadkat JD. Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3. Am J Physiol Gastrointest Liver Physiol. 2009;296:G910–22.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hsu CL, Lin W, Seshasayee D, Chen YH, Ding X, Lin Z, Suto E, Huang Z, Lee WP, Park H, Xu M, Sun M, Rangell L, Lutman JL, Ulufatu S, Stefanich E, Chalouni C, Sagolla M, Diehl L, Fielder P, Dean B, Balazs M, Martin F. Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis. Science. 2011;335:89–92.

    Article  PubMed  CAS  Google Scholar 

  • Johnson ZL, Cheong CG, Lee SY. Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Ã…. Nature. 2012;483:489–93.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kang N, Jun AH, Bhutia YD, Kannan N, Unadkat JD, Govindarajan R. Human equilibrative nucleoside transporter-3 (hENT3) spectrum disorder mutations impair nucleoside transport, protein localization, and stability. J Biol Chem. 2010;285:28343–52.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kim T, Ramesh V, Dworak M, Choi DS, McCarley RW, Kalinchuk AV, Basheer R. Disrupted sleep-wake regulation in type 1 equilibrative nucleoside transporter knockout mice. Neuroscience. 2015;303:211–9.

    Article  PubMed  CAS  Google Scholar 

  • Kost S, Sun C, Xiong W, Graham K, Cass CE, Young JD, Albensi BC, Parkinson FE. Behavioral effects of elevated expression of human equilibrative nucleoside transporter 1 in mice. Behav Brain Res. 2011;224:44–9.

    Article  PubMed  CAS  Google Scholar 

  • Li H, Smolen GA, Beers LF, Xia L, Gerald W, Wang J, Haber DA, Lee SB. Adenosine transporter ENT4 is a direct target of EWS/WT1 translocation product and is highly expressed in desmoplastic small round cell tumor. PLoS One. 2008;3:e2353.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nam HW, Lee MR, Zhu Y, Wu J, Hinton DJ, Choi S, Kim T, Hammack N, Yin JC, Choi DS. Type 1 equilibrative nucleoside transporter regulates ethanol drinking through accumbal N-methyl-D-aspartate receptor signaling. Biol Psychiatry. 2011;69:1043–51.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Parkinson FE, Damaraju VL, Graham K, Yao SYM, Baldwin SA, Cass CE, Young JD. Molecular biology of nucleoside transporters and their distributions and functions in the brain. Curr Top Med Chem. 2011;11:948–72.

    Article  PubMed  CAS  Google Scholar 

  • Rose JB, Naydenova Z, Bang A, Eguchi M, Sweeney G, Choi DS, Hammond JR, Coe IR. Equilibrative nucleoside transporter 1 plays an essential role in cardioprotection. Am J Physiol Heart Circ Physiol. 2010;298:H771–7.

    Article  PubMed  CAS  Google Scholar 

  • Slugoski MD, Smith KM, Mulinta R, Ng AML, Yao SYM, Morrison EL, Lee QOT, Zhang J, Karpinski E, Cass CE, Baldwin SA, Young JD. A conformationally mobile cysteine residue (Cys-561) modulates Na+ and H+ activation of human CNT3. J Biol Chem. 2008;283:24922–34.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Smith KM, Slugoski MD, Loewen SK, Ng AML, Yao SYM, Chen XZ, Karpinski E, Cass CE, Baldwin SA, Young JD. The broadly selective human Na+/nucleoside cotransporter (hCNT3) exhibits novel cation-coupled nucleoside transport characteristics. J Biol Chem. 2005;280:25436–49.

    Article  PubMed  CAS  Google Scholar 

  • Smith KM, Slugoski MD, Cass CE, Baldwin SA, Karpinski E, Young JD. Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3. Mol Membr Biol. 2007;24:53–64.

    Article  PubMed  CAS  Google Scholar 

  • Yao SY, Ng AM, Cass CE, Baldwin SA, Young JD. Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1). J Biol Chem. 2011;286:32552–62.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Young JD, Yao SYM, Baldwin JM, Cass CE, Baldwin SA. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol Asp Med. 2013;34:529–47.

    Article  CAS  Google Scholar 

  • Zhou MY, Duan HC, Engel K, Xia L. Wang adenosine transport by plasma membrane monoamine transporter: reinvestigation and comparison with organic cations. Drug Metab Dispos. 2010;38:1798–805.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. University of Alberta, Edmonton, AB, Canada

    Sylvia Y. M. Yao & James D. Young

Authors
  1. Sylvia Y. M. Yao
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  2. James D. Young
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Corresponding author

Correspondence to James D. Young .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Yao, S.Y.M., Young, J.D. (2018). SLC28 and SLC29. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101838

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