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Sirpa

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References

  • Barclay AN, van den Berg TK. The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target. Annu Rev Immunol. 2014;32:25–50. doi:10.1146/annurev-immunol-032713-120142.

    Article  PubMed  CAS  Google Scholar 

  • Chao MP, Weissman IL, Majeti R. The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications. Curr Opin Immunol. 2012;24:225–32. doi:10.1016/j.coi.2012.01.010.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gardai SJ, Xiao Y-Q, Dickinson M, Nick JA, Voelker DR, Greene KE, et al. By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell. 2003;115:13–23.

    Article  PubMed  CAS  Google Scholar 

  • Gitik M, Liraz-Zaltsman S, Oldenborg P-A, Reichert F, Rotshenker S. Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes. J Neuroinflammation. 2011;8:24. doi:10.1186/1742-2094-8-24.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, et al. Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice. J Exp Med. 2012;209:1325–34. doi:10.1084/jem.20101974.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ishikawa-Sekigami T, Kaneko Y, Okazawa H, Tomizawa T, Okajo J, Saito Y, et al. SHPS-1 promotes the survival of circulating erythrocytes through inhibition of phagocytosis by splenic macrophages. Blood. 2006;107:341–8. doi:10.1182/blood-2005-05-1896.

    Article  PubMed  CAS  Google Scholar 

  • Kanazawa Y, Saito Y, Supriatna Y, Tezuka H, Kotani T, Murata Y, et al. Role of SIRPα in regulation of mucosal immunity in the intestine. Genes Cells. 2010;15:1189–200. doi:10.1111/j.1365-2443.2010.01453.

    Article  PubMed  CAS  Google Scholar 

  • Liu X, Pu Y, Cron K, Deng L, Kline J, Frazier WA, et al. CD47 blockade triggers T cell-mediated destruction of immunogenic tumors. Nat Med. 2015;21:1209–15. doi:10.1038/nm.3931.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Maruyama T, Kusakari S, Sato-Hashimoto M, Hayashi Y, Kotani T, Murata Y, et al. Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain. J Neurochem. 2012;121:891–902. doi:10.1111/j.1471-4159.2012.07748.x.

    Article  PubMed  CAS  Google Scholar 

  • Matozaki T, Murata Y, Okazawa H, Ohnishi H. Functions and molecular mechanisms of the CD47-SIRPalpha signalling pathway. Trends Cell Biol. 2009;19:72–80. doi:10.1016/j.tcb.2008.12.001.

    Article  PubMed  CAS  Google Scholar 

  • Murata T, Ohnishi H, Okazawa H, Murata Y, Kusakari S, Hayashi Y, et al. CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc42. J Neurosci. 2006;26:12397–407. doi:10.1523/JNEUROSCI.3981-06.2006.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Murata Y, Kotani T, Ohnishi H, Matozaki T. The CD47-SIRPα signalling system: its physiological roles and therapeutic application. J Biochem. 2014;155:335–44. doi:10.1093/jb/mvu017.

    Article  PubMed  CAS  Google Scholar 

  • Nuvolone M, Kana V, Hutter G, Sakata D, Mortin-Toth SM, Russo G, et al. SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells. J Exp Med. 2013;210:2539–52. doi:10.1084/jem.20131274.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ohnishi H, Kaneko Y, Okazawa H, Miyashita M, Sato R, Hayashi A, et al. Differential localization of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 and CD47 and its molecular mechanisms in cultured hippocampal neurons. J Neurosci. 2005;25:2702–11. doi:10.1523/JNEUROSCI.5173-04.2005.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ohnishi H, Murata T, Kusakari S, Hayashi Y, Takao K, Maruyama T, et al. Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test. J Neurosci. 2010;30:10472–83. doi:10.1523/JNEUROSCI.0257-10.2010.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Okazawa H, Motegi S-I, Ohyama N, Ohnishi H, Tomizawa T, Kaneko Y, et al. Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system. J Immunol. 2005;174:2004–11.

    Article  PubMed  CAS  Google Scholar 

  • Oldenborg PA, Zheleznyak A, Fang YF, Lagenaur CF, Gresham HD, Lindberg FP. Role of CD47 as a marker of self on red blood cells. Science. 2000;288:2051–4.

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez PL, Harada T, Christian DA, Pantano DA, Tsai RK, Discher DE. Minimal “Self” peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles. Science. 2013;339:971–5. doi:10.1126/science.1229568.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Saito Y, Iwamura H, Kaneko T, Ohnishi H, Murata Y, Okazawa H, et al. Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues. Blood. 2010;116:3517–25. doi:10.1182/blood-2010-03-277244.

    Article  PubMed  CAS  Google Scholar 

  • Sato-Hashimoto M, Saito Y, Ohnishi H, Iwamura H, Kanazawa Y, Kaneko T, et al. Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen. J Immunol. 2011;187:291–7. doi:10.4049/jimmunol.1100528.

    Article  PubMed  CAS  Google Scholar 

  • Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, et al. Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/− mice improves engraftment of human hematopoietic cells in humanized mice. Proc Natl Acad Sci USA. 2011;108:13218–23. doi:10.1073/pnas.1109769108.

    Article  PubMed  PubMed Central  Google Scholar 

  • Takenaka K, Prasolava TK, Wang JCY, Mortin-Toth SM, Khalouei S, Gan OI, et al. Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Nat Immunol. 2007;8:1313–23. doi:10.1038/ni1527.

    Article  PubMed  CAS  Google Scholar 

  • Timms JF, Swanson KD, Marie-Cardine A, Raab M, Rudd CE, Schraven B, et al. SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages. Curr Biol. 1999;9:927–30.

    Article  PubMed  CAS  Google Scholar 

  • van Beek EM, Zarate JA, van Bruggen R, Schornagel K, Tool ATJ, Matozaki T, et al. SIRPα controls the activity of the phagocyte NADPH oxidase by restricting the expression of gp91(phox). Cell Rep. 2012;2:748–55. doi:10.1016/j.celrep.2012.08.027.

    Article  PubMed  CAS  Google Scholar 

  • Wang L, Lu Y, Deng S, Zhang Y, Yang L, Guan Y, et al. SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress. J Neurochem. 2012;122:834–43. doi:10.1111/j.1471-4159.2012.07818.x.

    Article  PubMed  CAS  Google Scholar 

  • Willingham SB, Volkmer J-P, Gentles AJ, Sahoo D, Dalerba P, Mitra SS, et al. The CD47-signal regulatory protein alpha (SIRPα) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci USA. 2012;109:6662–7. doi:10.1073/pnas.1121623109.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yamauchi T, Takenaka K, Urata S, Shima T, Kikushige Y, Tokuyama T, et al. Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment. Blood. 2013;121:1316–25. doi:10.1182/blood-2012-06-440354.

    Article  PubMed  CAS  Google Scholar 

  • Yanagita T, Murata Y, Tanaka D, Motegi S-I, Arai E, Daniwijaya EW, et al. Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy. JCI Insight. 2017;2:e89140. doi:10.1172/jci.insight.89140.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yi T, Li J, Chen H, Wu J, An J, Xu Y, et al. Splenic dendritic cells survey red blood cells for missing self-CD47 to trigger adaptive immune responses. Immunity. 2015;43:764–75. doi:10.1016/j.immuni.2015.08.021.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Correspondence to Yasuyuki Saito or Takashi Matozaki .

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Saito, Y., Murata, Y., Kotani, T., Matozaki, T. (2018). Sirpa. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101830

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