It traces back to the discovery of a protease from metamorphosed tadpole about 60 years ago by Jerome Gross, which eventually opened a new field of metalloprotease biochemistry (Gross and Lapiere 1962). The protease discovered then was an interstitial collagenase, also known as matrix metalloproteinase-1 (MMP-1) that involved in extracellular matrix (ECM) degradation. The complete protease repertoire of human accounting ∼2% of whole genome holds a great treasure of information on human health and diseases. All proteases are classified into five classes, namely, serine, threonine, cysteine, aspartic, and metalloproteinase proteases. Metalloprotease encompasses metzincin superfamily, which is further divided into five groups, e.g., astacin, serralysin, adamlysin, pappalysin, and matrixins (Lopez-Otin and Matrisian 2007). MMPs (or matrixins) are calcium-dependent zinc containing endopeptidases and members of metzincin...