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Plasminogen Activator, Urokinase Receptor

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

CD87; Monocyte activation antigen Mo3; PLAUR; uPAR; u-PAR; U-Plasminogen Activator Receptor from 2; URKR; Urokinase plasminogen activator surface receptor

Historical Background

In 1988 and 1989, respectively, Nielsen et al. and Estreicher et al. reported that the cell surface urokinase-type plasminogen activator (UPA) receptor was a 40- to 60-kD protein (Nielsen et al. 1988; Estreicher et al. 1989). Subsequent cloning of the human UPA receptor (uPAR) cDNA in 1990 showed that the primary structure of this receptor consists of 313 amino acid residues (Roldan et al. 1990). The entire uPAR sequence was found to be a triplicate of a cysteine-rich consensus sequence of about 90 amino acid residues suggesting that the origin of the uPAR might be an internal triplication of an ancestral gene (Behrendt et al. 1990, 1991).

uPAR is a receptor located in the plasma membrane of cells. However, one unusual feature of uPAR is its linkage to the plasma membrane via a...

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Authors and Affiliations

  1. Nephrology Service and Kidney Transplant Unit, Hospital Británico de Buenos Aires, Perdriel 74 (1280), Buenos Aires, Argentina

    Hernán Trimarchi

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  1. Hernán Trimarchi
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Correspondence to Hernán Trimarchi .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Trimarchi, H. (2018). Plasminogen Activator, Urokinase Receptor. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101811

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