Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

SGK-1 (Serum- and Glucocorticoid-Inducible Kinase-1)

  • David Della-Morte
  • Donatella Pastore
  • Barbara Capuani
  • Francesca Pacifici
  • Davide Lauro
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101807

Synonyms

Historical Background

The serum- and glucocorticoid-inducible kinase-1 (SGK-1) was originally cloned in 1993 by Webster et al., as an immediate early gene transcriptionally stimulated by serum and glucocorticoids in rat mammary tumor cells (Webster et al. 1993a, b). Few years later, the human isoform was cloned and characterized as a putative serine/threonine protein kinase transcriptionally modified during alterations of cell volume in human hepatoma cell line (Waldegger et al. 1997). The gene encoding human SGK-1 was localized to chromosome 6q23 (Waldegger et al. 1998). Subsequently were identified two novel isoforms homologous of SGK-1, the SGK-2 and SGK-3, that share 80% amino acid sequence identity in their catalytic domain with SGK-1 (Kobayashi et al. 1999). SGK kinases are expressed in a wide variety of species such as Caenorhabditis elegans and yeast that express two orthologs, Ypk1 and Ypk2 (Lauro et al. 2015). In...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • David Della-Morte
    • 1
    • 2
  • Donatella Pastore
    • 1
  • Barbara Capuani
    • 1
  • Francesca Pacifici
    • 1
  • Davide Lauro
    • 1
  1. 1.Department of Systems Medicine, School of MedicineUniversity of Rome Tor VergataRomeItaly
  2. 2.IRCCS San Raffaele PisanaRomeItaly