Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Neurogenins

  • Roberta Azzarelli
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101798

Synonyms

 Neurogenin1 [Neurog1; Ngn1; Math4C; bHLHa6; Neurod3];  Neurogenin2 [Neurog2; Ngn2; Math4A; bHLHa8; Atoh4];  Neurogenin3 [Neurog3; Ngn3; Math4B; bHLHa7; Atoh5]

Historical Background

Neurogenins (Neurog or Ngn) belong to a family of proneural proteins that play essential roles in cell fate determination during neurogenesis (Fig. 1a). They belong to a large class of basic helix-loop-helix (bHLH) transcription factors, which contains a conserved helix-loop-helix dimerization domain and a basic region providing DNA-binding activity (Fig. 1b) (Guillemot 1999). Proneural bHLH genes are both necessary and sufficient to initiate neuronal differentiation in a cell-autonomous manner and they are expressed at the correct time and place to select neural precursors for neuronal commitment.
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References

  1. Ali F, Hindley C, McDowell G, Deibler R, Jones A, Kirschner M, Guillemot F, Philpott A. Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis. Development. 2011;138:4267–77.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Anthwal N, Pelling M, Claxton S, Mellitzer G, Collin C, Kessaris N, Richardson WD, Gradwohl G, Ang SL. Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity. Dis Model Mech. 2013;6:1133–45.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Azzarelli R, Hardwick LJ, Philpott A. Emergence of neuronal diversity from patterning of telencephalic progenitors. Wiley Interdiscip Rev Dev Biol. 2015;4:197–214.CrossRefPubMedGoogle Scholar
  4. Bertrand N, Castro DS, Guillemot F. Proneural genes and the specification of neural cell types. Nat Rev Neurosci. 2002;3:517–30.CrossRefPubMedGoogle Scholar
  5. Fode C, Ma Q, Casarosa S, Ang SL, Anderson DJ, Guillemot F. A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons. Genes Dev. 2000;14:67–80.PubMedPubMedCentralGoogle Scholar
  6. Gohlke JM, Armant O, Parham FM, Smith MV, Zimmer C, Castro DS, Nguyen L, Parker JS, Gradwohl G, Portier CJ, et al. Characterization of the proneural gene regulatory network during mouse telencephalon development. BMC Biol. 2008;6:15.PubMedPubMedCentralCrossRefGoogle Scholar
  7. Gradwohl G, Dierich A, LeMeur M, Guillemot F. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA. 2000;97:1607–11.PubMedPubMedCentralCrossRefGoogle Scholar
  8. Guillemot F. Vertebrate bHLH genes and the determination of neuronal fates. Exp Cell Res. 1999;253:357–64.CrossRefPubMedGoogle Scholar
  9. Heinrich C, Blum R, Gascon S, Masserdotti G, Tripathi P, Sanchez R, Tiedt S, Schroeder T, Gotz M, Berninger B. Directing astroglia from the cerebral cortex into subtype specific functional neurons. PLoS Biol. 2010;8:e1000373.PubMedPubMedCentralCrossRefGoogle Scholar
  10. Heng J, Guillemot F. Proneural proteins and the development of the cerebral cortex. In: Cortical development: neural diversity and neocortical organization. 2013; Tokyo: Springer. p 54419–41.  https://doi.org/10.1007/978-4-431-54496-8.CrossRefGoogle Scholar
  11. Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, Skowronska-Krawczyk D, Bedogni F, Matter JM, Hevner R, et al. Neurogenin 2 controls cortical neuron migration through regulation of Rnd2. Nature. 2008;455:114–8.CrossRefPubMedGoogle Scholar
  12. Li S, Mattar P, Zinyk D, Singh K, Chaturvedi CP, Kovach C, Dixit R, Kurrasch DM, Ma YC, Chan JA, et al. GSK3 temporally regulates neurogenin 2 proneural activity in the neocortex. J Neurosci. 2012;32:7791–805.CrossRefPubMedGoogle Scholar
  13. Ma Q, Kintner C, Anderson DJ. Identification of neurogenin, a vertebrate neuronal determination gene. Cell. 1996;87:43–52.PubMedCrossRefGoogle Scholar
  14. Masserdotti G, Gillotin S, Sutor B, Drechsel D, Irmler M, Jorgensen HF, Sass S, Theis FJ, Beckers J, Berninger B, et al. Transcriptional mechanisms of proneural factors and REST in regulating neuronal reprogramming of astrocytes. Cell Stem Cell. 2015;17:74–88.PubMedPubMedCentralCrossRefGoogle Scholar
  15. Mellitzer G, Bonne S, Luco RF, Van De Casteele M, Lenne-Samuel N, Collombat P, Mansouri A, Lee J, Lan M, Pipeleers D, et al. IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J. 2006;25:1344–52.PubMedPubMedCentralCrossRefGoogle Scholar
  16. Sancho R, Gruber R, Gu G, Behrens A. Loss of Fbw7 reprograms adult pancreatic ductal cells into alpha, delta, and beta cells. Cell Stem Cell. 2014;15:139–53.PubMedPubMedCentralCrossRefGoogle Scholar
  17. Serafimidis I, Rakatzi I, Episkopou V, Gouti M, Gavalas A. Novel effectors of directed and Ngn3-mediated differentiation of mouse embryonic stem cells into endocrine pancreas progenitors. Stem Cells. 2008;26:3–16.CrossRefPubMedGoogle Scholar
  18. Shimojo H, Ohtsuka T, Kageyama R. Oscillations in notch signaling regulate maintenance of neural progenitors. Neuron. 2008;58:52–64.CrossRefPubMedGoogle Scholar
  19. Sommer L, Ma Q, Anderson DJ. neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol Cell Neurosci. 1996;8:221–41.CrossRefGoogle Scholar
  20. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature. 2008;455:627–32.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Wellcome Trust Centre for Stem Cell Research and Department of OncologyUniversity of CambridgeCambridgeUK