Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 1
The contraction and relaxation of skeletal muscle is regulated by the concomitant rise and fall of the cytoplasmic calcium level. The Ca2+ is released from the sarcoplasmic reticulum by ryanodine receptor and taken back to the SR by SERCA pumps. The idea of a relaxing factor had been put forward for a long time by many researchers seeking for control mechanism of muscle function. The successful candidate was found in a high-speed pellet of rabbit white skeletal muscle capable of hydrolyzing ATP in Ca2+- and Mg2+-dependent manner and requiring the presence of phospholipids. The dependence on phospholipids and incompatibility to detergents implicated that self-forming sealed vesicles accumulated...
- Sahoo SK, Shaikh SA, Sopariwala DH, Bal NC, Periasamy M. Sarcolipin protein interaction with sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) is distinct from phospholamban protein, and only sarcolipin can promote uncoupling of the SERCA pump. J Biol Chem. 2013;288:6881–9.PubMedPubMedCentralCrossRefGoogle Scholar