Originally cloned in 1993 from human heart cDNA, G protein-coupled receptor kinase 5 (GRK5) is a serine/threonine kinase and the fifth member of the GRK family to be discovered (Kunapuli and Benovic 1993). Proteins of the GRK family are categorized into subgroups that are based upon kinase homology, amino acid sequence similarity, and tissue expression patterns. These subgroups are: the rhodopsin kinase subfamily (GRK1 and GRK7), the β-adrenergic receptor kinase (β-ARK) subfamily (GRK2 and GRK3), and the GRK4-like subfamily (GRK4, GRK5, and GRK6) (Nagayama et al. 1996; Xu et al. 2014).
Structure, Function, and Regulation
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