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Encyclopedia of Signaling Molecules pp 1182–1191Cite as

Complement Factor H (CFH)

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Synonyms

AHUS1 (Hemolytic uremic syndrome atypical 1); AMBP1 (Adrenomedullin binding protein-1); ARMD4 (Age-related macular degeneration-4); ARMS1 (Age-related maculopathy susceptibility 1); FH (Factor H); HF1 (H factor 1 complement); HF; HF2

Historical Background

The complement system, the major noncellular component of the innate immune system, is composed of three different pathways: the classical (CP), the lectin (LP), and the alternative pathway (AP). These pathways participate in several processes, including tagging pathogens for phagocytosis, directing destruction of microorganisms, promoting inflammation, contributing to immune complex regulation, and linking the innate and adaptive immune systems. The complement system has two fundamental properties: discriminates self (e.g., host cells) from nonself (e.g., pathogens) and regulates itself to prevent unwanted damage. These properties, common to all arms of the immune system, are required for proper protection and maintenance of...

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Authors and Affiliations

  1. Oakland University William Beaumont School of Medicine, 2200 North Squirrel Road, Rochester, MI, USA

    Eduardo Lamas-Basulto, Anne M. Dersch & Claudio Cortes

Authors
  1. Eduardo Lamas-Basulto
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  2. Anne M. Dersch
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  3. Claudio Cortes
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Corresponding author

Correspondence to Claudio Cortes .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Lamas-Basulto, E., Dersch, A.M., Cortes, C. (2018). Complement Factor H (CFH). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101784

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