Neurofibromatosis type 2 (NF2) is a tumor suppressor gene that when deleted or mutated causes a disorder with the same name. This condition is primarily characterized by benign tumors of the nervous system such as bilateral vestibular schwannomas – originating from Schwann cell – in addition to meningiomas and ependymomas, which arise from cells that make up the membrane surrounding the brain and spinal cord and from the ependyma, a tissue of the central nervous system, respectively (Petrilli and Fernandez-Valle 2016). The incidence ratio of this dominantly inherited disease is 1:25,000, and 50–60% of cases are caused by de novo mutations with somatic mosaicism. NF2somatic mutations have also been found in...
NIH R01CA138850 and Breast Cancer Research Foundation of Alabama (BCRFA) grants to L.A.S.