Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

N-Myc and STAT Interactor (NMI)

  • Brandon J. Metge
  • Hawley C. Pruitt
  • Lalita A. Shevde
  • Rajeev S. Samant
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101778

Synonyms

Historical Background

N-myc interactor, NMI, was first characterized as an interactor of c-Myc and n-Myc using a yeast two-hybrid screen. Since its initial discovery, NMI has been studied for its roles in viral pathologies and more extensively for its role in cancer progression. However, literature describing the role of NMI function in normal physiology is relatively unknown aside from inferences from its roles in various pathologies. NMI is a protein mostly studied for its associations with known transcription factors. In humans, expression profiling has determined that NMI is expressed in all fetal tissues except in the brain and primarily in the adult spleen, liver, and kidneys. The human NMI gene is located on chromosome 2q23 and contains three exons that can form four alternatively spliced mRNA transcripts; two with no retained introns code for protein products (Bao and Zervos 1996). NMI’s expression is largely...
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Notes

Acknowledgments

NIH R01CA194048 grant to R.S.S.

References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Brandon J. Metge
    • 1
  • Hawley C. Pruitt
    • 1
  • Lalita A. Shevde
    • 2
  • Rajeev S. Samant
    • 1
    • 3
  1. 1.Division of Molecular and Cellular Pathology, Department of PathologyUniversity of Alabama at Birmingham, Wallace Tumor InstituteBirminghamUSA
  2. 2.Division of Molecular and Cellular Pathology, Department of Pathology and Comprehensive Cancer CenterUniversity of Alabama at Birmingham, Wallace Tumor InstituteBirminghamUSA
  3. 3.Department of Pathology and Comprehensive Cancer CenterThe University of AlabamaBirminghamUSA