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Encyclopedia of Signaling Molecules pp 2909–2918Cite as

MAGI2/S-SCAM

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Synonyms

In human: ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM

In mouse: AIP-1, Acvri1, Acvrinp1, Acvrip1, Magi-2, S-SCAM, mKIAA0705

In rat: Acvrinp1, Acvrip1, S-SCAM

Historical Background

MAGI stands for membrane-associated guanylate kinase with an inverted arrangement of protein-protein interaction domains. Human genome has three MAGI genes (MAGI1, MAGI2, and MAGI3). The encoded proteins belong to the membrane-associated guanylate kinases (MAGUKs) and are collectively called MAGI family proteins. Other MAGUKs, such as ZO-1, PSD-95, and CASK, harbor the guanylate kinase (GK) domain in the C-terminal region, while MAGI family proteins have the GK domain in the N-terminal region (Funke et al. 2005). For this, MAGI family proteins are claimed to have an inverted arrangement of protein-protein interaction domains. Human MAGI2, rat MAGI2, and mouse MAGI2 were identified as an interacting protein with atrophin-1, synapse-associated protein 90-associated proteins (SAPAPs), and activin...

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Authors and Affiliations

  1. Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

    Xiaoyin Xu, Manami Kodaka, Hiroaki Iwasa & Yutaka Hata

  2. Department of Breast Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

    Xiaoyin Xu

  3. Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, Japan

    Yutaka Hata

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  1. Xiaoyin Xu
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  2. Manami Kodaka
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  3. Hiroaki Iwasa
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  4. Yutaka Hata
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Correspondence to Yutaka Hata .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Xu, X., Kodaka, M., Iwasa, H., Hata, Y. (2018). MAGI2/S-SCAM. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101774

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