MAGI stands for membrane-associated guanylate kinase with an inverted arrangement of protein-protein interaction domains. Human genome has three MAGI genes (MAGI1, MAGI2, and MAGI3). The encoded proteins belong to the membrane-associated guanylate kinases (MAGUKs) and are collectively called MAGI family proteins. Other MAGUKs, such as ZO-1, PSD-95, and CASK, harbor the guanylate kinase (GK) domain in the C-terminal region, while MAGI family proteins have the GK domain in the N-terminal region (Funke et al. 2005). For this, MAGI family proteins are claimed to have an inverted arrangement of protein-protein interaction domains. Human MAGI2, rat MAGI2, and mouse MAGI2 were identified as an interacting protein with atrophin-1, synapse-associated protein 90-associated proteins (SAPAPs), and activin...
- Dong L, Pietsch S, Tan Z, Perner B, Sierig R, Kruspe D, et al. Integration of cistromic and transcriptomic analyses identifies Nphs2, Mafb, and Magi2 as Wilms’ tumor 1 target genes in podocyte differentiation and maintenance. J Am Soc Nephrol. 2015;26:2118–28.PubMedPubMedCentralCrossRefGoogle Scholar
- Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, et al. Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. J Neurosci. 2002;22:1280–9.CrossRefPubMedGoogle Scholar
- Landsend AS, Amiry-Moghaddam M, Matsubara A, Bergersen L, Usami S, Wenthold RJ, et al. Differential localization of delta glutamate receptors in the rat cerebellum: coexpression with AMPA receptors in parallel fiber-spine synapses and absence from climbing fiber-spine synapses. J Neurosci. 1997;17:834–42.CrossRefPubMedGoogle Scholar
- Mok H, Shin H, Kim S, Lee JR, Yoon J, Kim E. Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins. J Neurosci. 2002;22:5253–8.CrossRefPubMedGoogle Scholar
- Sumita K, Sato Y, Iida J, Kawata A, Hamano M, Hirabayashi S, et al. Synaptic scaffolding molecule (S-SCAM) membrane-associated guanylate kinase with inverted organization (MAGI)-2 is associated with cell adhesion molecules at inhibitory synapses in rat hippocampal neurons. J Neurochem. 2007;100:154–66.CrossRefPubMedGoogle Scholar
- Xu J, Paquet M, Lau AG, Wood JD, Ross CA, Hall RA. Beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95. J Biol Chem. 2001;276:41310–7.CrossRefPubMedGoogle Scholar
- Yamada A, Irie K, Deguchi-Tawarada M, Ohtsuka T, Takai Y. Nectin-dependent localization of synaptic scaffolding molecule (S-SCAM) at the puncta adherentia junctions formed between the mossy fibre terminals and the dendrites of pyramidal cells in the CA3 area of the mouse hippocampus. Genes Cells. 2003;8:985–94.CrossRefPubMedGoogle Scholar