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Encyclopedia of Signaling Molecules pp 4200–4211Cite as

Protein Disulfide Isomerase

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Synonyms

PDI; Protein disulfide isomerase family A

Historical Background

The dithiol-disulfide oxidoreductase protein disulfide isomerase (PDI) was discovered in 1963 as the first protein folding chaperone. Research groups led by Brunó Straub (Venetianer and Straub 1963) and Christian B. Anfinsen (Goldberger et al. 1963) independently made pivotal discoveries about an enzyme that reactivated reduced ribonuclease. Straub and coworkers purified the reactivating system from chicken pancreas. Anfinsen studied the system in conjunction with his Nobel-prize-winning work on ribonuclease and purified a system with similar activity from rat liver microsomes. In 1972, the enzyme was given the name protein disulfide isomerase and its official classification number, EC 5.3.4.1. The newly purified protein was identified as the “ribonuclease-reactivating enzyme” and was nearly identical to glutathione-insulin transhydrogenase, causing confusion in the field (Bjelland et al. 1983). Both enzymes...

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Acknowledgments

We acknowledge financial support from the National Cancer Institute, NIH (CA193690).

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Authors and Affiliations

  1. Department of Medicinal Chemistry, College of Pharmacy, Translational Oncology Program, University of Michigan, Ann Arbor, MI, USA

    Andrea Shergalis & Nouri Neamati

Authors
  1. Andrea Shergalis
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  2. Nouri Neamati
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Corresponding author

Correspondence to Nouri Neamati .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Shergalis, A., Neamati, N. (2018). Protein Disulfide Isomerase. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101768

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