Reference work entry
CYR61/CCN1 belongs to the family of CCN matricellular proteins, first described 25 years ago. The other members consist of CTGF/CCN2 (connective tissue growth factor) and NOV/CCN3 (neuroblastoma overexpressed) and Wnt-induced signaling pathway proteins 1–3 (CCN4–CCN6). They constitute a family of proteins with conserved domain structures (Fig. 1). CCN1 was first described as an immediate early gene induced by mitogens in fibroblasts (O’Brien et al. 1990). It has now been implicated in numerous biological processes such as cell adhesion, migration, proliferation, and death with altered expression in cancer or vascular diseases (Emre and Imhof 2014).
- Huang YT, Lan Q, Ponsonnet L, Blanquet M, Christofori G, Zaric J, Ruegg C. The matricellular protein CYR61 interferes with normal pancreatic islets architecture and promotes pancreatic neuroendocrine tumor progression. Oncotarget. 2016;7:1663–74. doi:10.18632/oncotarget.6411.CrossRefPubMedPubMedCentralGoogle Scholar
- Lobel M, Bauer S, Meisel C, Eisenreich A, Kudernatsch R, Tank J, Rauch U, Kuhl U, Schultheiss HP, Volk HD, Poller W, Scheibenbogen C. CCN1: a novel inflammation-regulated biphasic immune cell migration modulator. Cell Mol Life Sci: CMLS. 2012;69:3101–13. doi:10.1007/s00018-012-0981-x.CrossRefPubMedPubMedCentralGoogle Scholar
- Yang GP, Lau LF. Cyr61, product of a growth factor-inducible immediate early gene, is associated with the extracellular matrix and the cell surface. Cell Growth Differ: The Mol Biol J Am Assoc Cancer Res. 1991;2:351–7.Google Scholar
- Zhang Q, Wu J, Cao Q, Xiao L, Wang L, He D, Ouyang G, Lin J, Shen B, Shi Y, Zhang Y, Li D, Li N. A critical role of Cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Rheum. 2009;60:3602–12. doi:10.1002/art.24999.CrossRefPubMedPubMedCentralGoogle Scholar
- Zhu X, Xiao L, Huo R, Zhang J, Lin J, Xie J, Sun S, He Y, Sun Y, Zhou Z, Shen B, Li N. Cyr61 is involved in neutrophil infiltration in joints by inducing IL-8 production by fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther. 2013;15:R187. doi:10.1186/ar4377.CrossRefPubMedPubMedCentralGoogle Scholar
© Springer International Publishing AG 2018