Synonyms
LEM6; Ligand effect modulator 6; Peroxisome proliferative-activated receptor, gamma, coactivator 1, alpha; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC1; PGC1A; PGC-1-alpha; PGC-1v; PPAR gamma coactivator variant form; PPAR gamma coactivator-1; PPAR-gamma coactivator 1-alpha; PPARGC1; PPARGC1A; PPARGC-1-alpha; PRGC1
Historical Background
PGC-1α is the founding member of a small family of transcriptional coactivators that also includes PGC-1β and PRC (PGC-1-related coactivator). The three members of the family share structural features and exert their regulatory action on gene expression by binding and coactivating an overlapping wide range of transcription factors and nuclear receptors. Although each of the PGC-1 coactivators exhibits some specific functional peculiarities, particularly in the cellular context or physiological situation in which they exert their function, the three members of the family are nowadays considered key players in the...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, et al. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature. 2008;451(7181):1008–12. doi:nature06613 [pii].
Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev. 2004;84(1):277–359. doi:10.1152/physrev.00015.2003.
Chang JS, Fernand V, Zhang Y, Shin J, Jun HJ, Joshi Y, et al. NT-PGC-1alpha protein is sufficient to link beta3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis. J Biol Chem. 2012;287(12):9100–11. doi:M111.320200 [pii].
Chinsomboon J, Ruas J, Gupta RK, Thom R, Shoag J, Rowe GC, et al. The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle. Proc Natl Acad Sci U S A. 2009;106(50):21401–6. doi:0909131106 [pii].
Handschin C, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev. 2006;27(7):728–35. doi:er.2006-0037 [pii].
Hock MB, Kralli A. Transcriptional control of mitochondrial biogenesis and function. Annu Rev Physiol. 2009;71:177–203. doi:10.1146/annurev.physiol.010908.163119.
Knutti D, Kaul A, Kralli AA. tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol Cell Biol. 2000;20(7):2411–22.
Lin J, PH W, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 2004;119(1):121–35. doi:10.1016/j.cell.2004.09.013.
Martinez-Redondo V, Pettersson AT, Ruas JL. The hitchhiker's guide to PGC-1alpha isoform structure and biological functions. Diabetologia. 2015;58(9):1969–77. doi:10.1007/s00125-015-3671-z.
Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, Spiegelman BM. Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. Mol Cell. 2000;6(2):307–16. doi:S1097-2765(00)00031-9 [pii].
Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998;92(6):829–39. doi:S0092-8674(00)81410-5 [pii].
Villena JA. New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond. FEBS J. 2015;282(4):647–72. doi:10.1111/febs.13175.
Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 1999;98(1):115–24. doi:S0092-8674(00)80611-X [pii].
Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 2001;413(6852):131–8. doi:10.1038/35093050. 35093050 [pii].
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this entry
Cite this entry
Villena, J.A. (2018). PGC-1a. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101752
Download citation
DOI: https://doi.org/10.1007/978-3-319-67199-4_101752
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences