Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Melatonin Receptor MT1 and MT2

  • Atsuro Oishi
  • Ralf Jockers
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101751

Synonyms

Historical Background

Melatonin (N-acetyl-5-methoxytryptamine) is an evolutionary old molecule which is derived from the essential amino acid tryptophan in a four-step biosynthesis pathway. Melatonin is synthesized by many organisms as diverse as bacteria, protists, fungi, macroalgae, plants, and animals. During evolution, several functions of melatonin appeared including protection of cells against oxidative stress, regulation of circadian rhythmicity, and ciliary swimming in invertebrates. The function of melatonin further expanded in mammals (see below). In mammals, the synthesis of melatonin is regulated by light and by...

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Notes

Acknowledgments

We would like to acknowledge Dr. Erika Cecon for reading the manuscript and helpful suggestions.

This work was supported by the Fondation de la Recherche Médicale (Equipe FRM DEQ20130326503), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS) and the “Who am I?” laboratory of excellence No.ANR-11-LABX-0071 funded by the French Government through its “Investments for the Future” program operated by the French National Research Agency (ANR) under grant No.ANR-11-IDEX-0005-01.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Institut Cochin, INSERM, U1016, CNRS 8104, Université Paris DescartesParisFrance