Melatonin Receptor MT1 and MT2
Melatonin receptor MT1:
Melatonin receptor MT2:
Melatonin (N-acetyl-5-methoxytryptamine) is an evolutionary old molecule which is derived from the essential amino acid tryptophan in a four-step biosynthesis pathway. Melatonin is synthesized by many organisms as diverse as bacteria, protists, fungi, macroalgae, plants, and animals. During evolution, several functions of melatonin appeared including protection of cells against oxidative stress, regulation of circadian rhythmicity, and ciliary swimming in invertebrates. The function of melatonin further expanded in mammals (see below). In mammals, the synthesis of melatonin is regulated by light and by...
We would like to acknowledge Dr. Erika Cecon for reading the manuscript and helpful suggestions.
This work was supported by the Fondation de la Recherche Médicale (Equipe FRM DEQ20130326503), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS) and the “Who am I?” laboratory of excellence No.ANR-11-LABX-0071 funded by the French Government through its “Investments for the Future” program operated by the French National Research Agency (ANR) under grant No.ANR-11-IDEX-0005-01.
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