Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

PTX3

  • Raffaella Parente
  • Barbara Bottazzi
  • Alberto Mantovani
  • Antonio Inforzato
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101746

Synonyms

Historical Background

Innate immunity sets in evolution as the earliest line of defense against pathogens. Endowed with pivotal roles in activation and orientation of the adaptive immune response, this ancient system is deeply involved in a number of physiological and pathological processes, ranging from tissue homeostasis to cancer growth and development. Innate immunity comprises a cellular and humoral arm, the latter encompassing soluble pattern recognition molecules (PRMs) that recognize pathogen- and danger-associated molecular patterns (PAMPs and DAMPs, respectively) and initiate the immune response in coordination with the cellular arm (Bottazzi et al. 2010). Pentraxins are a phylogenetically conserved superfamily of soluble PRMs that, based on primary structure, is divided into two subfamilies: short and long pentraxins. Prototypes of the short pentraxins, C-reactive protein (CRP), and serum amyloid P (SAP)...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Raffaella Parente
    • 1
  • Barbara Bottazzi
    • 1
  • Alberto Mantovani
    • 1
    • 2
  • Antonio Inforzato
    • 1
    • 3
  1. 1.Department of Inflammation and ImmunologyHumanitas Clinical and Research CenterRozzanoItaly
  2. 2.Humanitas UniversityRozzanoItaly
  3. 3.Department of Medical Biotechnologies and Translational MedicineUniversity of MilanMilanItaly