Miro (Mitochondrial Rho)
The Ras superfamily family of small GTPases consists of GTP binding-dependent molecular switches with diverse cellular functions. Two isoforms of an “atypical” Rho GTPases, named mitochondrial Rho (Miro), are the first identified mitochondrial-associated Ras superfamily members (Fransson et al. 2003). Evolutionary conserved Miro GTPase has been identified in humans (Fransson et al. 2003), yeast (Frederick et al. 2004), Drosophila (Guo et al. 2005), as well as plant (Yamaoka and Leaver 2008).
Functional studies of Miro in various organisms have suggested critical roles of Miro in regulating mitochondrial morphology (Fransson et al. 2003), inheritance (Frederick et al. 2004), and mitochondrial calcium homeostasis (Lee et al. 2016). It is also a key regulator of cytoskeleton-mediated, long-range mitochondrial transport in...