Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Platelet-Activating Factor Acetylhydrolase (Pafah)

  • Gopal Kedihithlu Marathe
  • Shancy Petsel Jacob
  • Mosale Seetharam Sumanth
  • Chikkamenahalli Lakshminarayana Lakshmikanth
  • Kandahalli Venkataranganayaka Abhilash
  • Vyala Hanumanthareddy Chaithra
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101737

Synonyms

Historical Background

Platelet activating factor-acetylhydrolases (PAF-AH) (EC 3.1.1.47) are essentially phospholipase A 2 isoenzymes (Group VII and VIII) catalyzing the hydrolysis of short chain acyl group at the second position of phospholipids. An important bioactive lipid that led to the discovery of PAF-AH is platelet-activating factor (PAF), a potent proinflammatory lipid, whose discovery in the early 1970s was a breakthrough that opened a new dimension to the role of phospholipids, until then they were only considered as structural constituents of biological membranes/lipoproteins or at the most precursor for the biologically active phosphoinositides and eicosanoids (Hanahan 1986; Prescott et al. 2000). In 1970, Henson and colleagues (Henson 1970) first proposed the presence of a fluid phase mediator released by sensitized rabbit leukocytes capable...
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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Gopal Kedihithlu Marathe
    • 1
  • Shancy Petsel Jacob
    • 1
  • Mosale Seetharam Sumanth
    • 1
  • Chikkamenahalli Lakshminarayana Lakshmikanth
    • 1
  • Kandahalli Venkataranganayaka Abhilash
    • 1
  • Vyala Hanumanthareddy Chaithra
    • 1
  1. 1.Department of Studies in BiochemistryUniversity of MysoreMysuruIndia