Nonmuscle Myosin II
Heavy chain: NMMHC-II; MHCII; zipper (in Drosophila). Three isoforms are expressed in mammalian cells, also known as: (1) MHCII-A; myosin-9= MHA= FTNS= EPSTS= BDPLT6= DFNA17= NMMHCA= NMHC-II-A= NMMHC-IIA; (2) MHCII-B=myosin-10= NMMHCB= NMMHC-IIB; (3) MHCII-C=myosin-14= DFNA4= DFNA4A= FP17425= MHC16= MYH17= NMHC II-C= NMHC-II-C= PNMHH= myosin. Arabic numbers are now used too, e.g., myosin 2
Regulatory light chain: RLC; MLC; MRLC; MYRL; spaghetti squash (in Drosophila). Three isoforms are expressed in mammalian cells, also known as: (1) SM (smooth muscle)-RLC= MYL9= LC20= MLC-2C= MLC2= MRLC1= MYRL2; (2) MYL12A= HEL-S-24= MLC-2B= MLCB= MRCL3= MRLC3= MYL2B; (3) MYL12B= MLC-B=MRLC2
Essential light chain: MYL6= ELC= MLC= MLC-ALK= MLC1 (in Drosophila)
Functional unit (2×HC+2×RLC+2×ELC): NMII, NMMII, cytoplasmic myosin II
The discovery of nonmuscle myosin II (NMII) is linked to the story of muscle contraction (reviewed in Szent-Gyorgyi 2004). It started in...
We regret the large number of original articles that were left out due to space constraints. Dr. Vicente-Manzanares would like to thank Prof. Robert S. Adelstein, Dr. Mary Anne Conti and Dr. Xuefei Ma for critical reading of the manuscript and their advice, help and warm friendship over the years. This work was funded by grant SAF2014-54705-R from MINECO. Miguel Vicente-Manzanares is a Ramon y Cajal Assistant Professor (RYC2010-06094).
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