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Neutral Ceramidase

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References

  • Airola MV, Allen WJ, Pulkoski-Gross MJ, Obeid LM, Rizzo RC, Hannun YA. Structural basis for ceramide recognition and hydrolysis by human neutral ceramidase. Structure. 2015;23:1482–91.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • El Bawab S, Birbes H, Roddy P, Szulc ZM, Bielawska A, Hannun YA. Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. J Biol Chem. 2001;276:16758–66.

    Article  CAS  PubMed  Google Scholar 

  • Garcia-Barros M, Coant N, Kawamori T, Wada M, Snider AJ, Truman JP, Wu BX, Furuya H, Clarke CJ, Bialkowska AB, Ghaleb A, Yang VW, Obeid LM, Hannun YA. Role of neutral ceramidase in colon cancer. FASEB J. 2016;30:4159–71. https://doi.org/10.1096/fj.201600611R.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gatt S. Enzymic hydrolysis and synthesis of ceramides. J Biol Chem. 1963;238:3131–3.

    CAS  PubMed  Google Scholar 

  • Inoue T, Okino N, Kakuta Y, Hijikata A, Okano H, Goda HM, Tani M, Sueyoshi N, Kambayashi K, Matsumura H, Kai Y, Ito M. Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase. J Biol Chem. 2009;284:9566–77.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ito M, Okino N, Tani M. New insight into the structure, reaction mechanism, and biological functions of neutral ceramidase. Biochim Biophys Acta. 2014;1841:682–91.

    Article  CAS  PubMed  Google Scholar 

  • Kono M, Dreier JL, Ellis JM, Allende ML, Kalkofen DN, Sanders KM, Bielawski J, Bielawska A, Hannun YA, Proia RL. Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. J Biol Chem. 2006;281:7324–31.

    Article  CAS  PubMed  Google Scholar 

  • Mitsutake S, Tani M, Okino N, Mori K, Ichinose S, Omori A, Iida H, Nakamura T, Ito M. Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney. J Biol Chem. 2001;276:26249–59.

    Article  CAS  PubMed  Google Scholar 

  • Novgorodov SA, Riley CL, Yu J, Borg KT, Hannun YA, Proia RL, Kindy MS, Gudz TI. Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury. J Biol Chem. 2014;289:13142–54.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Okino N, Ichinose S, Omori A, Imayama S, Nakamura T, Ito M. Molecular cloning, sequencing, and expression of the gene encoding alkaline ceramidase from Pseudomonas aeruginosa. Cloning of a ceramidase homologue from Mycobacterium tuberculosis. J Biol Chem. 1999;274:36616–22.

    Article  CAS  PubMed  Google Scholar 

  • Okino N, Mori K, Ito M. Genomic structure and promoter analysis of the mouse neutral ceramidase gene. Biochem Biophys Res Commun. 2002;299:160–6.

    Article  CAS  PubMed  Google Scholar 

  • Snider AJ, Wu BX, Jenkins RW, Sticca JA, Kawamori T, Hannun YA, Obeid LM. Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. Prostaglandins Other Lipid Mediat. 2012;99:124–30.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sundaram K, Mather AR, Marimuthu S, Shah PP, Snider AJ, Obeid LM, Hannun YA, Beverly LJ, Siskind LJ. Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. Biochem J. 2016;473:743–55.

    Article  PubMed  CAS  Google Scholar 

  • Tani M, Ito M, Igarashi Y. Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space. Cell Signal. 2007;19:229–37.

    Article  CAS  PubMed  Google Scholar 

  • Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M. Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized. J Biol Chem. 2000a;275:3462–8.

    Article  CAS  PubMed  Google Scholar 

  • Tani M, Okino N, Mori K, Tanigawa T, Izu H, Ito M. Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases. J Biol Chem. 2000b;275:11229–34.

    Article  CAS  PubMed  Google Scholar 

  • Uchida Y, Houben E, Park K, Douangpanya S, Lee YM, Wu BX, Hannun YA, Radin NS, Elias PM, Holleran WM. Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB. J Invest Dermatol. 2010;130:2472–80.

    Article  CAS  PubMed  Google Scholar 

  • Yavin E, Gatt S. Enzymatic hydrolysis of sphingolipids. 8. Further purification and properties of rat brain ceramidase. Biochemistry. 1969;8:1692–8.

    Article  CAS  PubMed  Google Scholar 

  • Yoshimura Y, Tani M, Okino N, Iida H, Ito M. Molecular cloning and functional analysis of zebrafish neutral ceramidase. J Biol Chem. 2004;279:44012–22.

    Article  CAS  PubMed  Google Scholar 

  • Zhu Q, Jin JF, Shan XH, Liu CP, Mao XD, Xu KF, Liu C. Chronic activation of neutral ceramidase protects beta-cells against cytokine-induced apoptosis. Acta Pharmacol Sin. 2008;29:593–9.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Motohiro Tani .

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Tani, M., Ito, M. (2018). Neutral Ceramidase. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101723

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