NDFIP1 and NDFIP2
Bypass Sod1p Defects (Bsd2p) (Saccharomyces cerevisiae); Nedd4 family-interacting protein 1 (Ndfip1); Nedd4 family-interacting protein (Ndfip), dNdfip, DmeI, CG32177 (Drosophila Ndfip1); NEDD4 WW domain-binding protein 5 (human); Nedd4 WW domain-binding protein 5 (N4WBP5)
Ndfips and Immunity
Ndfips and Brain Injury
Ndfips and Metabolism
Ndfip1 has also been implicated in pancreatic function through its role in regulating JunB (Beck et al. 2015). In pancreatic β cells, expression of Ndfip1 resulted in ER stress due to both the degradation of JunB (a potent inhibitor of ER stress) and the inhibition of the unfolded protein response that serves to protect cells against ER stress. This then prevents insulin secretion, induces caspase activity, and leads to β cell death (Beck et al. 2015).
Ndfips are highly conserved proteins that primarily regulate the function of the Nedd4 family of ubiquitin ligases in their role in regulating substrates through ubiquitination. Generation of knockout mouse models has revealed the importance of these proteins both in maintaining normal homeostasis in physiological systems such as the immune system and iron regulation and during injury or disease as shown in the brain’s response to traumatic brain injury. Given their ubiquitous expression pattern, it is likely that these proteins have as yet undiscovered roles in other tissues or systems.
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