NEDD4–2 (neural precursor cell expressed, developmentally downregulated 4-like) encoded by the Nedd4L gene, belongs to the NEDD4 family of ubiquitin protein ligases. NEDD4 family members are HECT-type ubiquitin ligases (E3) that act at the final step of the ubiquitin cascade to accept ubiquitin from a ubiquitin-conjugating enzyme (E2) and transfer it to their cognate substrates. Ubiquitination of a protein often targets it for degradation; however it may also affect protein localization, trafficking, and recognition by signaling or regulatory complexes. The other members of the NEDD4 family include NEDD4, ITCH, SMURF1, SMURF2, WWP1, WWP2, NEDL1, and NEDL2 (Rotin and Kumar 2009).
NEDD4–2 (originally submitted in the database as mouse KIAA0439 or human NEDD4Lgene) is most closely related to the founding member, NEDD4, which was originally identified in the early embryonic central nervous system as a developmentally...
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