Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

HGF (Hepatocyte Growth Factor)

  • Hiroki Sato
  • Shunsuke Aoki
  • Takashi Kato
  • Kunio Matsumoto
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101701

Synonyms

Historical Background

In 1984, hepatocyte growth factor (HGF) was first reported as a potent mitogen of rat hepatocytes in a primary culture. The primary structure of HGF became evident with cDNA cloning in 1989, and HGF was simultaneously identified as a novel growth factor (Nakamura et al. 1989; Miyazawa et al. 1989). Meanwhile, scatter factor was identified from fibroblast-cultured media as a scattering-inducible factor toward epithelial cells. The biological activities of HGF and scatter factor seemed unrelated, but subsequent biochemical analysis has revealed that HGF and scatter factor are identical.

Initially, a transforming Met fusion protein, translocated promoter region (TPR)–Met, was discovered in a human osteosarcoma cell line as an active oncogene (Cooper et al. 1984). The proto-oncogene c-Met was later found to encode the transmembrane protein with intracellular tyrosine...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Hiroki Sato
    • 1
  • Shunsuke Aoki
    • 2
  • Takashi Kato
    • 3
  • Kunio Matsumoto
    • 1
  1. 1.Division of Tumor Dynamics and Regulation, Cancer Research InstituteKanazawa UniversityKanazawaJapan
  2. 2.Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems EngineeringKyushu Institute of TechnologyIizuka-shiJapan
  3. 3.Department of Pharmacology, Faculty of MedicineKinki UniversitySayamaJapan