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Ku70 and Ku80

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Encyclopedia of Signaling Molecules

Synonyms

Ku70; Ku69; X-ray repair cross-complementing 6 (XRCC6); Lupus Ku autoantigen protein p70; ATP-dependent DNA helicase 2 subunit 1; X-ray repair complementing defective repair in Chinese hamster cells 6. Ku80; Ku86; X-ray repair cross- complementing 5 (XRCC5); Lupus Ku autoantigen protein p80; X-ray repair complementing defective repair in Chinese ham ster cells 6; ATP-dependent DNA helicase 2 subunit 2. 17 2 subunit 2. Ku70/80 heterodimer; Ku70/80; Ku(p70/p80); ku heterodimer.

Historical Background

The Ku70/80 heterodimer (also named Lupus Ku autoantigen protein p70 and Lupus Ku autoantigen protein p80) was first isolated from sera of systemic lupus erythematosus patients (LSE) (Reeves 1987). LSE is an autoimmune disease, whereby the immune system mistakenly attacks healthy tissue, resulting in red rash, as a response of inflammation. Both the Ku70 and Ku80 subunits were subcloned (Reeves and Sthoeger 1989; Mimori et al. 1990), but the breakthrough occurred with the discovery...

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References

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Author information

Authors and Affiliations

  1. Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark

    Guido Keijzers

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  1. Guido Keijzers
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Correspondence to Guido Keijzers .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Keijzers, G. (2018). Ku70 and Ku80. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101685

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