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Lysophosphatidic Acid Receptor

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References

  • Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, et al. Crystal structure of antagonist bound human lysophosphatidic acid receptor 1. Cell. 2015;161(7):1633–43. Epub 2015/06/20

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Fukushima N, Ishii S, Tsujiuchi T, Kagawa N, Katoh K. Comparative analyses of lysophosphatidic acid receptor-mediated signaling. Cell Mol Life Sci. 2015;72(12):2377–94 .Epub 2015/03/04

    Article  CAS  PubMed  Google Scholar 

  • Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, et al. Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes. Int Immunol. 2016;28(6):283–92. Epub 2015/12/31

    Article  CAS  PubMed  Google Scholar 

  • Hecht JH, Weiner JA, Post SR, Chun J. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol. 1996;135(4):1071–83.

    Article  CAS  PubMed  Google Scholar 

  • Ishii I, Fukushima N, Ye X, Chun J. Lysophospholipid receptors: signaling and biology. Annu Rev Biochemist. 2004;73:321–54.

    Article  CAS  Google Scholar 

  • Kihara Y, Maceyka M, Spiegel S, Chun J. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Br J Pharmacol. 2014;171:3575–94.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lee MJ, Van Brocklyn JR, Thangada S, Liu CH, Hand AR, Menzeleev R, et al. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science. 1998;279(5356):1552–5.

    Article  CAS  PubMed  Google Scholar 

  • Lee CW, Rivera R, Gardell S, Dubin AE, Chun J. GPR92 as a new G12/13 and Gq coupled lysophosphatidic acid receptor that increases cAMP: LPA5. J Biol Chem. 2006;281:23589–97.

    Article  CAS  PubMed  Google Scholar 

  • Li G, Mosier PD, Fang X, Zhang Y. Toward the three-dimensional structure and lysophosphatidic acid binding characteristics of the LPA(4)/p2y(9)/GPR23 receptor: a homology modeling study. J Mol Graph Model. 2009;28(1):70–9. Epub 2009/05/09

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Noguchi K, Ishii S, Shimizu T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem. 2003;278(28):25600–6.

    Article  CAS  PubMed  Google Scholar 

  • Oh DY, Yoon JM, Moon MJ, Hwang JI, Choe H, Lee JY, et al. Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. J Biol Chem. 2008;283(30):21054–64. Epub 2008/05/24

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Pasternack SM, von Kugelgen I, Al Aboud K, Lee YA, Ruschendorf F, Voss K, et al. G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nat Genet. 2008;40(3):329–34. Epub 2008/02/26

    Article  CAS  PubMed  Google Scholar 

  • Raza SI, Muhammad D, Jan A, Ali RH, Hassan M, Ahmad W, et al. In silico analysis of missense mutations in LPAR6 reveals abnormal phospholipid signaling pathway leading to hypotrichosis. PLoS ONE. 2014;9:e104756.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, et al. Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell. 2009;138(6):1222–35.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tsujiuchi T, Hirane M, Dong Y, Fukushima N. Diverse effects of LPA receptors on cell motile activities of cancer cells. J Recept Signal Transduct Res. 2014;34(3):149–53. Epub 2014/01/28

    Article  CAS  PubMed  Google Scholar 

  • Valentine WJ, Fells JI, Perygin DH, Mujahid S, Yokoyama K, Fujiwara Y, et al. Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptors. J Biol Chem. 2008;283(18):12175–87. Epub 2008/03/05

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • van Corven EJ, Groenink A, Jalink K, Eichholtz T, Moolenaar WH. Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins. Cell. 1989;59(1):45–54.

    Article  PubMed  Google Scholar 

  • Williams JR, Khandoga AL, Goyal P, Fells JI, Perygin DH, Siess W, et al. Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J Biol Chem. 2009;284(25):17304–19. Epub 2009/04/16

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yanagida K, Masago K, Nakanishi H, Kihara Y, Hamano F, Tajima Y, et al. Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. J Biol Chem. 2009;284(26):17731–41.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yung YC, Stoddard NC, Chun J. LPA receptor signaling: pharmacology, physiology, and pathophysiology. J Lipid Res. 2014;55(7):1192–214. Epub 2014/03/20

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Acknowledgments

This work was supported by KINDAI research funding KD02 (N.F. and T.T.) and KINDAI School of Science and Engineering funding RK-052 and RK-062 (N.F.). We apologize to all authors whose primary research papers could not be cited directly due to space limitations.

Author information

Authors and Affiliations

  1. Division of Molecular Neurobiology, Department of Life Science, Kindai University, Higashiosaka, 577-8502, Japan

    Nobuyuki Fukushima & Tsuyoshi Kado

  2. Division of Molecular Oncology, Department of Life Science, Kindai University, Higashiosaka, 577-8502, Japan

    Toshifumi Tsujiuchi

Authors
  1. Nobuyuki Fukushima
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  2. Tsuyoshi Kado
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  3. Toshifumi Tsujiuchi
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Corresponding author

Correspondence to Nobuyuki Fukushima .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Fukushima, N., Kado, T., Tsujiuchi, T. (2018). Lysophosphatidic Acid Receptor. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101681

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