Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Src-Like Adapter Protein 2 (SLAP2)

  • Sausan A. Moharram
  • Lars Rönnstrand
  • Julhash U. Kazi
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101669

Synonyms

 C20orf156;  MARS;  SLA2;  SLAP-2

Historical Background

Src-like adaptor protein 2 (SLAP2) was initially identified as an inhibitory protein of antigen receptor-mediated activation of lymphocytes (Holland et al. 2001). The SLAP family of proteins consists of two members, SLAP and SLAP2. Both SLAP and SLAP2 share similar structural features with SRC (Fig. 1). SLAP2 is expressed in a wide range of tissues including bone marrow, macrophages and hematopoietic cell lines (Kazi et al. 2015). Mice with targeted deletion of either SLAP2 or both SLAP and SLAP2 have been described with a weak phenotype (Dragone et al. 2009). However, SLAP2 has been shown to play important roles in antigen receptors and receptor tyrosine kinase signaling (Kazi et al. 2015).
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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Sausan A. Moharram
    • 1
  • Lars Rönnstrand
    • 1
  • Julhash U. Kazi
    • 1
    • 2
  1. 1.Division of Translational Cancer Research, Department of Laboratory MedicineLund UniversityLundSweden
  2. 2.Laboratory of Computational Biochemistry, KN Biomedical Research InstituteBarisalBangladesh