Ephrin Receptor A2
Erythropoietin-producing human hepatocellular carcinoma receptors (EPH) have been discovered through a screening aimed at identifying novel kinases involved in cancer (Holland et al. 1997). They form the largest subfamily of receptor tyrosine kinases (RTKs) and are among the oldest evolutionarily conserved receptor/ligand pairs (Pasquale 2008). EPH receptors and their ephrin (EFNs) ligands are expressed in all embryonic germ layers of vertebrates and mediate cell migration and positioning, boundary formation, and segmentation during important developmental processes such as gastrulation (Pasquale 2008). Axon guidance is one of the main functions of EPHs/EFNs; however, this system is nowadays regarded as a universal cell-to-cell communication pathway that allows cellular moving to a specific position and maintains cellular organization through chemotactic/chemorepulsive forces (Pasquale 2008; Genander 2012). Recent...
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