Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

IDH1 (Isocitrate Dehydrogenase 1)

  • Ivi Juliana Bristot
  • Fernanda Stapenhorst França
  • Fábio KlamtEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101639


Historical Background

The IDH1 gene on chromosome 2 encodes the cytosolic isoenzyme of isocitrate dehydrogenase, enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate (alpha-KG). Hogeboom and Schneider were researching the intracellular distribution of the enzymes responsible for the reactions of the Krebs tricarboxylic cycle when they first reported this enzyme in cytosol in 1950 (Hogeboom and Schneider 1950). Chen and collaborators found that IDH1 was consistent with a dimeric molecular structure, that the gene locus is probably autosomal, and it is different from the mitochondrial locus of isocitrate dehydrogenase (Chen et al. 1972). The single subunit of the enzyme is 414 amino acids long with an estimated molecular mass of 46.65 kDa and contains a...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Ivi Juliana Bristot
    • 1
  • Fernanda Stapenhorst França
    • 1
  • Fábio Klamt
    • 1
    Email author
  1. 1.Laboratory of Cellular Biochemistry, Department of Biochemistry, Institute of Basic Health Science (ICBS)Federal University of Rio Grande do Sul (UFRGS)Porto AlegreBrazil