The ETS family is one of the largest families of transcriptional regulators, which was initially derived from the leukemia virus, E26 (E-twenty-six). This virus carried the v-ets oncogene, which was initially discovered as part of the gag-myb-ets transforming fusion protein of E26 and it can cause mixed erythroid-myeloid and lymphoid leukemia. The founding member of this family is Ets1. Based on their homology with highly conserved DNA-binding domain, the ETS domain, many other ETS-domain proteins have been identified from various organisms (Sharrocks 2001). The number of ETS transcription factors is much more in vertebrates compared to invertebrate metazoans: while in Drosophila and Caenorhabditis elegans, 8 and 10 genes, respectively, are present, in vertebrates 26 or more members of this family have been found (Hart et...
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