NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2)
HZF-3; Immediate-early response protein NOT; NGFI-B/Nur77 beta-type transcription factor homolog; NOT; Nuclear receptor related 1; Nuclear receptor subfamily 4 group A member 2; Nurr1; Orphan nuclear receptor NURR1; RNR1; T-cell nuclear receptor NOT; TINUR; Transcriptionally inducible nuclear receptor; Transcriptionally inducible nuclear receptor related
Orphan nuclear receptor Nurr1, also known as nuclear receptor subfamily 4, group A, member 2 (NR4A2), together with Nur77 (NR4A1) and Nor1 (NR4A3), is a member of the steroid/thyroid hormone nuclear receptor superfamily. Unlike the other nuclear receptors, Nurr1 is an immediate early gene, and its transcription can be induced by various stimuli such as depolarization, cAMP, inflammation, hormones, calcium, and growth factors (Volpicelli et al. 2004). Structurally, Nurr1 lacks a hydrophobic pocket for ligand binding and might function as ligand-independent nuclear receptor (Wang et al. 2016)....