GHSR: Growth Hormone Secretagogue Receptor
Growth hormone secretagogue receptor (GHSR) was first cloned from human hypothalamus and pituitary, with the function of binding growth hormone secretagogue (Howard et al. 1996). Both peptidyl and nonpeptidyl growth hormone secretagogues could activate the GHSR on membrane of somatotroph cells from anterior-pituitary (McKee et al. 1997). Three years later, its endogenous ligand was found in rat stomach extract by Kojima et al. This endogenous ligand for GHSR was named as ghrelin because ghr is the Proto-Indo-European root for grow (Kojima et al. 1999).
GHSR plays important roles in many canonical physiological functions when activated by its endogenous ligand ghrelin. Ghrelin is a 28 amino acid peptide released into blood in response to hormonal or neural signals. Activation of GHSR requires a unique octanoylation of the third amino acid serine of ghrelin. The...
This work was supported by grants from the National Natural Science Foundation of China (81330010, 81390354) and American Diabetes Association grant #1-13-BS-225.
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