Reference work entry
ΔFosB is encoded by the FosB gene and shares homology with other Fos family transcription factors, which include c-Fos, FosB, Fra1, and Fra2. All Fos family proteins heterodimerize with Jun family proteins (c-Jun, JunB, or JunD) to form active AP1 (activator protein-1) transcription factors that bind to AP1 sites (consensus sequence: TGAC/GTCA) present in the promoters of certain genes to regulate their transcription. The genes encoding Fos family proteins are termed immediate early genes based on their rapid induction in a cell-type-specific manner in diverse tissues, including neurons in the intact brain, in response to a wide range of acute stimuli. All of these Fos family proteins, however, and their mRNA transcripts are highly unstable, which causes them to return to basal levels within hours of the stimulus. ΔFosB is unique among Fos family proteins in exhibiting a very different induction profile (Hope et al. 1994; Hiroi et al. 1997...
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