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Encyclopedia of Signaling Molecules pp 1821–1836Cite as

Forkhead Box Protein O

  • Reference work entry
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Synonyms

AF6q21; AFX; DAF-16; dFoxO; FKH1; FKHR; FKHRL1; FKHRL1P2; FoxO1; FoxO1a; FoxO3; FoxO3a; FoxO4; FoxO6

Background

Forkhead box (Fox) proteins are a family of transcription factors that regulate the transcription of genes regulating diverse cellular processes, including cell survival, apoptosis, oxidative stress response and redox signaling, proliferation, differentiation, metabolism, and life span. Fox proteins are classified into subclasses FoxA–FoxS, and subgroup O (FoxO) proteins are a subgroup of the Fox family, which is characterized by a conserved DNA-binding domain (the “Forkhead box,” or Fox). This domain could recognize the specific DNA sequence localized in the promoter and thus regulate the transcription/expression of these genes. Forkhead gene (fkh) was cloned for the first time from the fly Drosophila melanogaster and has been identified to play important roles during the developing process of the anterior and posterior gut of the embryo. Genetic mutation in fkh...

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Acknowledgments

This research was financially supported by the Guangdong Provincial Project of Science and Technology (2011B050200005), the National Natural Science Foundation of China (31371088), SRG2015-00004-FHS and MYRG2016-00052-FHS from University of Macau, and the Science and Technology Development Fund (FDCT) of Macao (FDCT 021/2015/A1).

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Authors and Affiliations

  1. Faculty of Health Sciences, University of Macau, Room 4021, Building E12, Avenida de Universidade, Taipa, Macau, China

    Haitao Wang & Wenhua Zheng

  2. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China

    Haitao Wang

  3. School of Pharmacy Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

    Philip Lazarovici

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  1. Haitao Wang
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  2. Philip Lazarovici
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  3. Wenhua Zheng
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Correspondence to Wenhua Zheng .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Wang, H., Lazarovici, P., Zheng, W. (2018). Forkhead Box Protein O. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101601

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