CD151 antigen; CD151 antigen (Raph blood group); GP27; Hemidesmosomal tetraspanin CD151; Membrane glycoprotein SFA-1; MER2; PETA-3; Platelet endothelial tetraspan antigen-3; Platelet surface glycoprotein gp27; Platelet-endothelial cell tetraspan antigen 3; Platelet-endothelial tetraspan antigen 3; RAPH; Tetraspanin-24; TSPAN24; Tspan-24
CD151 also known as GP-27/MER-2/PETA-3/RAPH/SFA-1/TSPAN-24 belongs to tetraspanin superfamily. It is a plasma membrane protein which forms a “tetraspanin web” and a stable laminin-binding complex with integrins α3β1: α6β1 and α3β1:α6β4 in kidney and skin (Sterk et al. 2002). It acts as a membrane receptor, forms tetraspanin-enriched microdomains (TEMs) which serve as molecular facilitator (Zoller 2009), involved in intracellular signaling (Yauch et al. 1998). It plays vital role in cell proliferation and death (Zhang et al. 2001). It is associated with differential neural development and cognitive function,...
This work was supported by GITAM University, Visakhapatnam, India and funded by Department of Science and Technology (DST), New Delhi, India.
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