Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Almahariq M, Mei FC, Cheng X. Cyclic AMP sensor EPAC proteins and energy homeostasis. Trends Endocrinol Metab. 2014;25:60–71. https://doi.org/10.1016/j.tem.2013.10.004.
Almahariq M, Mei FC, Cheng X. The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention. Acta Biochim Biophys Sin Shanghai. 2016;48:75–81. https://doi.org/10.1093/abbs/gmv115.
Banerjee U, Cheng X. Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: structure, function and therapeutics. Gene. 2015;570:157–67. https://doi.org/10.1016/j.gene.2015.06.063.
Bisserier M, Blondeau JP, Lezoualc’h F. Epac proteins: specific ligands and role in cardiac remodelling. Biochem Soc Trans. 2014;42(2):257–64. https://doi.org/10.1042/BST20140033.
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc’h F. Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications. Cell Signal. 2011;23(8):1257–66. https://doi.org/10.1016/j.cellsig.2011.03.007.
Chen H, Wild C, Zhou X, Ye N, Cheng X, Zhou J. Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC). J Med Chem. 2014;57(9):3651–65. https://doi.org/10.1021/jm401425e.
de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature. 1998;396(6710):474–7. https://doi.org/10.1038/24884.
Dekkers BG, Racké K, Schmidt M. Distinct PKA and Epac compartmentalization in airway function and plasticity. Pharmacol Ther. 2013;137:248–65. https://doi.org/10.1016/j.pharmthera.2012.10.006.
Gloerich M, Bos JL. Epac: defining a new mechanism for cAMP action. Annu Rev Pharmacol Toxicol. 2010;50:355–75. https://doi.org/10.1146/annurev.pharmtox.010909.105714.
Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM. A family of cAMP-binding proteins that directly activate Rap1. Science. 1998;282(5397):2275–9.
Laurent AC, Breckler M, Berthouze M, Lezoualc’h F. Role of Epac in brain and heart. Biochem Soc Trans. 2012;40:51–7. https://doi.org/10.1042/BST20110642.
Lezoualc’h F, Fazal L, Laudette M, Conte C. Cyclic AMP Sensor EPAC proteins and their role in cardiovascular function and disease. Circ Res. 2016;118:881–97. https://doi.org/10.1161/CIRCRESAHA.115.306529.
Métrich M, Berthouze M, Morel E, Crozatier B, Gomez AM, Lezoualc’h F. Role of the cAMP-binding protein Epac in cardiovascular physiology and pathophysiology. Pflugers Arch. 2010;459:535–46. https://doi.org/10.1007/s00424-009-0747-y.
Parnell E, Palmer TM, Yarwood SJ. The future of EPAC-targeted therapies: agonism versus antagonism. Trends Pharmacol Sci. 2015;36:203–14. https://doi.org/10.1016/j.tips.2015.02.003.
Schmidt M, Dekker FJ, Maarsingh H. Exchange protein directly activated by cAMP (Epac): a multidomain cAMP mediator in the regulation of diverse biological functions. Pharmacol Rev. 2013;65:670–709. https://doi.org/10.1124/pr.110.003707.
Sugawara K, Shibasaki T, Takahashi H, Seino S. Structure and functional roles of Epac2 (Rapgef4). Gene. 2016;575:577–83. https://doi.org/10.1016/j.gene.2015.09.029.
Acknowledgments
F. Lezoualc’h was supported by grants from Institut National de la Santé et de la Recherche Médicale, Fondation pour la Recherche Médicale (Programme “Equipes FRM 2016”, DEQ20160334892), Fondation de France (00066331) and Université de Toulouse.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this entry
Cite this entry
Conte, C., Lezoualc’h, F. (2018). Epac. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101595
Download citation
DOI: https://doi.org/10.1007/978-3-319-67199-4_101595
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences