Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

NBCe1 Electrogenic Na+-Coupled HCO3−(CO32−) Transporter

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DOI: https://doi.org/10.1007/978-3-319-67199-4_101572
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Synonyms

Electrogenic sodium bicarbonate cotransporter 1; NBCe1

Historical Background: SLC4 Gene Transporter Family

The NBCe1 transporter belongs to the SLC4 gene family whose 10 members are homologous membrane transport proteins that differ in their ability to transport Na+, Cl−, HCO3−(CO32−), H+, NH3, and water (Kurtz 2013; Parker and Boron 2013; Liu et al. 2015). AE1, AE2, and AE3 (SLC4A1, −2, −3, respectively) mediate the electroneutral exchange of Cl− and HCO3−. The SLC4A9 gene encodes AE4 has previously been reported to function as a Cl−/HCO3− exchanger and electroneutral Na+-HCO3− cotransporter, but has recently been shown to mediate electroneutral monovalent cation (Na+/K+)-dependent Cl−/HCO3− exchange (Pena-Munzenmayer et al. 2016). NDCBE (encoded by SLC4A8) like AE1, AE2, and AE3 is an anion exchanger yet differs in that it couples the electroneutral transport of Na+ and HCO3− (or CO32−) in exchange for Cl−. NBCn1 (SLC4A7 gene) and NBCn2 (SLC4A10 gene) transport Na+-HCO3−...
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Notes

Acknowledgments

Dr. Kurtz is supported in part by funds from the NIH (R01-DK077162), the Allan Smidt Charitable Fund, the Factor Family Foundation Chair in Nephrology, and the Arvey Foundation.

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Division of NephrologyDavid Geffen School of Medicine, and Brain Research InstituteLos AngelesUSA