Cbl protein (for Casitas B-lineage lymphoma) was discovered as the cellular form of v-Cbl, a retroviral oncoprotein. v-Cbl is a 357 amino acid-long, gag-fusion transforming protein of Cas NS-1 retrovirus, which causes pre- and pro-B lymphomas in mice (Langdon et al. 1989). The cellular Cbl has a length of 906 or 913 amino acids in humans and mice, respectively, so v-Cbl corresponds to a large C-terminal truncation of Cbl (Blake et al. 1991). Following this finding, other Cbl-family members were identified and the role of Cbl-family proteins as key players in cellular regulation was established. The history of research in this area has been outlined in multiple review articles, for example, Tsygankov et al. (2001) and Swaminathan and Tsygankov (2006), etc. During the first years following the discovery of c-Cbl, the prevalent view was that it functions as an adaptor protein. The discovery of the E3 ubiquitin-protein ligase activity...
- Li M, Kales SC, Ma K, Shoemaker BA, Crespo-Barreto J, Cangelosi AL, et al. Balancing protein stability and activity in cancer: a new approach for identifying driver mutations affecting CBL ubiquitin ligase activation. Cancer Res. 2016;76:561–71. https://doi.org/10.1158/0008-5472.CAN-14-3812.CrossRefPubMedPubMedCentralGoogle Scholar
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